Article

Allosteric regulation of switch-II controls K-Ras oncogenicity

2022-09-21

Abstract excerpt

Ras proteins are GTPases that regulate a wide range of cellular processes. The activity of Ras is dependent on its nucleotide-binding status, which is modulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Previously, we demonstrated that mutation of lysine 104 to glutamine (K104Q) attenuates the transforming capacity of oncogenic K-Ras by interrupting GEF induced nucleotide...

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Literature Corpus work: 466229a1-516f-5592-9791-eaa7a1f8376d
DOI: 10.1101/2022.09.20.508702

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