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Article

KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation.

Biochemistry - 23 Jan 2018

Lu Jia, Bera Asim K, Gondi Sudershan, Westover Kenneth D

Abstract excerpt

KRAS switch loop movements play a crucial role in regulating RAS signaling, and alteration of these sensitive dynamics is a principal mechanism through which disease-associated RAS mutations lead to aberrant RAS activation. Prior studies suggest that despite a high degree of sequence similarity, the switches in KRAS are more dynamic than those in HRAS. We determined X-ray crystal structures of the rare...

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Source

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Identifiers

PMID: 29235861
DOI: 10.1021/acs.biochem.7b00974
PMCID: PMC8691853

Genes

KRAS
HRAS
RHO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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