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Article

Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity.

Cancer research - 2 Oct 2023

Yang Moon Hee, Tran Timothy H, Hunt Bethany, Agnor Rebecca, Johnson Christian W, Shui Bing, Waybright Timothy J, Nowak Jonathan A, Stephen Andrew G, Simanshu Dhirendra K, Haigis Kevin M

Abstract excerpt

RAS proteins are GTPases that regulate a wide range of cellular processes. RAS activity is dependent on its nucleotide-binding status, which is modulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). KRAS can be acetylated at lysine 104 (K104), and an acetylation-mimetic mutation of K104 to glutamine (K104Q) attenuates the in vitro-transforming capacity of oncogenic KRAS by...

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Identifiers

PMID: 37556505
DOI: 10.1158/0008-5472.CAN-22-3210
PMCID: PMC10592143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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