Article

DOCK7 regulates WNT signaling and NMJ clustering in normal and DMD muscle

2025-12-25

Abstract excerpt

Dedicator of cytokinesis (DOCK) proteins have diverse and critical roles in myoblast fusion, glucose metabolism, skeletal muscle regeneration, and neuronal polarity. DOCK7 is part of this 11-member family of atypical guanine exchange factors. While human DOCK7 pathogenic variants are rare, biallelic variants are known to result in hypotonia and ataxia in children. More recently, DOCK variants have been shown to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70ced2b4-a464-55d8-acf8-6e422047e182
DOI: 10.64898/2025.12.23.696254

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DOCK7 regulates WNT signaling and NMJ clustering in normal and DMD muscleDOI 10.64898/2025.12.23.696254Read

DOCK3 regulates normal skeletal muscle regeneration and glucose metabolismSemantic proximity Read

Heterozygous loss-of function variants in DOCK4 cause neurodevelopmental delay and microcephalySemantic proximity Read

Heterozygous loss-of-function variants in DOCK4 cause neurodevelopmental delay and microcephaly.Semantic proximity Read

RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor NeuronsSemantic proximity Read

The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.Semantic proximity Read

Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function.Semantic proximity Read

DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia.Semantic proximity Read

Base editing derived models of human <i>WDR34</i> and <i>WDR60</i> disease alleles replicate retrograde IFT and hedgehog signaling defects and suggest disturbed Golgi protein transportSemantic proximity Read

Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy.Semantic proximity Read

Nervous NDRGs: the N-myc downstream–regulated gene family in the central and peripheral nervous systemSemantic proximity Read

A founder variant expands the phenotype of WNT7B-related PDAC syndrome.Semantic proximity Read

A recurrent MCF2 variant which disrupts DCC binding leads to congenital mirror movements and corpus callosum agenesisSemantic proximity Read