Article

Glycoprotein 130 Antagonism Counteracts Metabolic and Inflammatory Alterations to Enhance Right Ventricle Function in Pulmonary Artery Banded Pigs

2025-01-22

Abstract excerpt

<h4>Background</h4> Right ventricular dysfunction (RVD) is a risk factor for death in multiple cardiovascular diseases, but RV-enhancing therapies are lacking. Inhibition of glycoprotein-130 (GP130) signaling with the small molecule SC144 improves RV function in rodent RVD via anti-inflammatory and metabolic mechanisms. However, SC144’s efficacy and molecular effects in a translational large animal model of RVD a...

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Literature Corpus work: f393485c-4a96-51e6-9d8e-6b6d6011d0a7
DOI: 10.1101/2025.01.20.633954

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