Article
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
Nature genetics - 13 Mar 2011
Mells George F, Floyd James A B, Morley Katherine I, Cordell Heather J, Franklin Christopher S, Shin So-Youn, Heneghan Michael A, Neuberger James M, Donaldson Peter T, Day Darren B, Ducker Samantha J, Muriithi Agnes W, Wheater Elizabeth F, Hammond Christopher J, Dawwas Muhammad F, Jones David E, Peltonen Leena, Alexander Graeme J, Sandford Richard N, Anderson Carl A
Abstract excerpt
In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have been identified in recent genome-wide association studies (GWAS). To identify additional loci, we carried out a GWAS using 1,840 cases from the UK PBC Consortium and 5,163 UK population controls as part of the Wellcome Trust Case Control Consortium 3 (WTCCC3). We followed up 28 loci in an additional UK cohort of 620...
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