Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci.

doi:10.1038/s41467-024-53602-w

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci.

Nature communications - 6 Nov 2024

Goode Elizabeth C, Fachal Laura, Panousis Nikolaos, Moutsianas Loukas, McIntyre Rebecca E, Bai Benjamin Yu Hang, Kawasaki Norihito, Wittmann Alexandra, Raine Tim, Rushbrook Simon M, Anderson Carl A

Abstract excerpt

Genome-wide association studies of primary sclerosing cholangitis have identified 23 susceptibility loci. The majority of these loci reside in non-coding regions of the genome and are thought to exert their effect by perturbing the regulation of nearby genes. Here, we aim to identify these genes to improve the biological understanding of primary sclerosing cholangitis, and nominate potential drug targets. We...

Topics

Cholangitis, Sclerosing
Humans
Genetic Predisposition to Disease
Quantitative Trait Loci
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Colitis, Ulcerative
Bayes Theorem
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Chromosome Mapping

Intracellular Signaling Peptides and Proteins

T-Lymphocytes

Adult

Middle Aged

Adaptor Proteins, Signal Transducing

Source

Open in PubMed Open full text

Identifiers

PMID: 39505854
DOI: 10.1038/s41467-024-53602-w
PMCID: PMC11541731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci.PMID 39505854Read ↗

Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.Semantic proximity Read ↗

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.Semantic proximity Read ↗

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.Semantic proximity Read ↗

The Genetics of Primary Biliary Cholangitis: A GWAS and Post-GWAS UpdateSemantic proximity Read ↗

Resolving inflammatory bowel disease risk variants to genes and cell typesSemantic proximity Read ↗

Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk lociSemantic proximity Read ↗

Multivariable genome-wide analysis elucidates the shared genetic architecture, immunosenescence features, and gut-origin therapeutic targets of ulcerative colitis-associated multisystem inflammation.Semantic proximity Read ↗

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.Semantic proximity Read ↗

Epidemiologic and genetic associations between primary biliary cholangitis and extrahepatic rheumatic diseases.Semantic proximity Read ↗

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.Semantic proximity Read ↗

Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism.Semantic proximity Read ↗

Integrative analysis of genetic and cellular interactions connecting inflammatory bowel disease and primary biliary cholangitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.