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The Genetics of Primary Biliary Cholangitis: A GWAS and Post-GWAS Update

3 Feb 2023

Abstract excerpt

Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which the small intrahepatic bile ducts are destroyed by autoimmune reactions. Among autoimmune diseases, which are polygenic complex traits caused by the combined contribution of genetic and environmental factors, PBC exhibits the strongest involvement of genetic heritability in disease development. As at December 2022,...

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PMID: 36833332
DOI: 10.3390/genes14020405

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