Causal associations between primary sclerosing cholangitis and systemic lupus erythematosus: Evidence from Mendelian randomization and transcriptomic analyses.

Abstract excerpt

Overlap between primary sclerosing cholangitis (PSC) and systemic lupus erythematosus (SLE) has been documented in previous studies, but the precise causal relationships between them remain elusive. This study aims to clarify the potential causal links between PSC and SLE using Mendelian randomization (MR) and transcriptomic analyses. Genome-wide association study (GWAS) summary data for PSC and SLE were obtained...

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