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Article

Structure of the MUC5AC VWD3 assembly responsible for the formation of net-like mucin polymers.

EMBO reports - 1 Mar 2025

Trillo-Muyo Sergio, Ermund Anna, Hansson Gunnar C

Abstract excerpt

Gel-forming mucins MUC5AC and MUC5B constitute the main structural component of the mucus in the respiratory system. Secreted mucins interact specifically with each other and other molecules giving mucus specific properties. We determined the cryoEM structures of the wild type D3 assembly of the human MUC5AC mucin and the structural single nucleotide polymorphisms (SNP) variants Arg996Gln and Arg1201Trp that...

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Share to Cryoelectron Microscopy
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 40016425
DOI: 10.1038/s44319-025-00395-8
PMCID: PMC11933400

Genes

MUC5AC
MUC5B

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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