Article
A SNP altering the MUC5AC mucin structure is increased in idiopathic pulmonary fibrosis together with the MUC5B SNP.
Respiratory research - 28 Jul 2026
Trillo-Muyo Sergio, Ermund Anna, Dolan Brendan, Akyürek Levent M, Magnusson Jesper M, Hansson Gunnar C
Abstract excerpt
BACKGROUND: The gel-forming mucins MUC5B and MUC5AC constitute the main structural components of mucus in the respiratory system where MUC5AC is known to form nets. The MUC5B (rs35705950) Single Nucleotide Polymorphism (SNP) has been shown to increase the risk for Idiopathic Pulmonary Fibrosis (IPF). The MUC5AC SNP rs878913005, common in European populations, results in an Arg1201Trp substitution, resulting in...
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