Article

Structural and genetic diversity in the secreted mucins, <i>MUC5AC</i> and <i>MUC5B</i>

2024-03-20

Abstract excerpt

<h4>ABSTRACT</h4> The secreted mucins MUC5AC and MUC5B play critical defensive roles in airway pathogen entrapment and mucociliary clearance by encoding large glycoproteins with variable number tandem repeats (VNTRs). These polymorphic and degenerate protein coding VNTRs make the loci difficult to investigate with short reads. We characterize the structural diversity of MUC5AC and MUC5B by long-read sequencing...

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Literature Corpus work: 0e0901c4-9baf-5e4c-855a-0c33ec7b3bb9
DOI: 10.1101/2024.03.18.585560

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