Article

IL-36γ signalling promotes a proinflammatory macrophage state that is associated with reduced lipid uptake

2025-10-23

Abstract excerpt

Macrophages exhibit remarkable functional plasticity, adopting immune activating or immune suppressive states in response to environmental cues. While these phenotypic shifts are essential to immune homeostasis, the mechanisms whereby they are regulated in humans are poorly understood. Here, we investigated the role of interleukin (IL)-36γ, a barrier cytokine that is strongly induced in response to infection. We s...

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Literature Corpus work: bdb286de-035c-5c48-b9ff-1ea1ccd1dbd3
DOI: 10.1101/2025.10.22.683795

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