Article

Toll Like Receptor 9 Pathway Mediates Schlafen <sup>+</sup> -MDSC Polarization During <i>Helicobacter</i> -Induced Gastric Metaplasias

2022-01-27

Abstract excerpt

<h4>Background and Aims</h4> A subset of MDSCs that express murine Schlafen4 (SLFN4) or its human ortholog SLFN12L polarize in the Helicobacter -inflamed stomach coincident with intestinal or spasmolytic polypeptide-expressing metaplasia (SPEM). We propose that individuals with a more robust response to damage-activated molecular patterns (DAMPs) and increased Toll-like receptor (TLR9) expression are predisposed...

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Literature Corpus work: 1b583b36-8781-5474-bcb4-eed8da673c1c
DOI: 10.1101/2022.01.25.477562

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