Article

Dual role of ZIC2 during neural induction: from pioneer transcription factor to enhancer activator

2025-07-24

Abstract excerpt

ZIC2, a member of the Zinc Finger of the Cerebellum family of transcription factors (TFs), plays crucial roles during neural development. In humans, defects in ZIC2 cause holoprosencephaly, a congenital brain malformation characterized by the defective cleavage of cerebral hemispheres due to problems in midline patterning. However, the gene regulatory network (GRN) controlled by ZIC2 and the regulatory mechanisms...

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Literature Corpus work: 122aa95e-f975-5303-8ee9-669420190841
DOI: 10.1101/2025.07.23.666365

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