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Genetic insights into the biological mechanisms governing human ovarian ageing

2021-01-15

Abstract excerpt

Reproductive longevity is critical for fertility and impacts healthy ageing in women, yet insights into the underlying biological mechanisms and treatments to preserve it are limited. Here, we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in ∼200,000 women of European ancestry. These common alleles influence clinical extremes of ANM; women in...

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Literature Corpus work
de553e55-da1f-50d0-ae5e-8a66271afcfd
DOI
10.1101/2021.01.11.20248322
Open publication

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Genetic insights into the biological mechanisms governing human ovarian ageingDOI 10.1101/2021.01.11.20248322
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