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Targeting NAD+ metabolism: dual roles in cancer treatment

4 Dec 2023

Abstract excerpt

Nicotinamide adenine dinucleotide (NAD + ) is indispensable for various oxidation-reduction reactions in mammalian cells, particularly during energy production. Malignant cells increase the expression levels of NAD + biosynthesis enzymes for rapid proliferation and biomass production. Furthermore, mounting proof has indicated that NAD-degrading enzymes (NADases) play a role in creating the immunosuppressive tumor...

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PMID: 38116009
DOI: 10.3389/fimmu.2023.1269896

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