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Formation of Multinucleated Osteoclasts Depends on an Oxidized Species of Cell Surface Associated La Protein

2024-05-05

Abstract excerpt

<h4>Summary</h4> The bone-resorbing activity of osteoclasts plays a critical role in the life-long remodeling of our bones that is perturbed in many bone loss diseases. Multinucleated osteoclasts are formed by the fusion of precursor cells, and larger cells - generated by an increased number of cell fusion events - have higher resorptive activity. We find that osteoclast fusion and bone-resorption are promoted by...

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Literature Corpus work
45e56185-399c-5ca9-a0c2-e04b14777c27
DOI
10.1101/2024.05.02.592254
Open publication

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Formation of Multinucleated Osteoclasts Depends on an Oxidized Species of Cell Surface Associated La ProteinDOI 10.1101/2024.05.02.592254
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