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Article

Heterogeneity and Actin Cytoskeleton in Osteoclast and Macrophage Multinucleation

10 Sept 2020

Abstract excerpt

Osteoclast signatures are determined by two transcriptional programs, the lineage-determining transcription pathway and the receptor activator of nuclear factor kappa-B ligand (RANKL)-dependent differentiation pathways. During differentiation, mononuclear precursors become multinucleated by cell fusion. Recently, live-cell imaging has revealed a high level of heterogeneity in osteoclast multinucleation. This...

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PMID: 32927783
DOI: 10.3390/ijms21186629

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