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Osteoclast Multinucleation: Review of Current Literature

8 Aug 2020

Abstract excerpt

Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic multinucleation process not only increases cell size but causes functional alterations through reconstruction of the cytoskeleton, creating the actin ring and ruffled border that enable bone resorption. Our understanding of the molecular mechanisms underlying osteoclast multinucleation has advanced considerably in this century,...

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PMID: 32784443
DOI: 10.3390/ijms21165685

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