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Article

The role of osteoclast differentiation and function in skeletal homeostasis

3 Nov 2015

Abstract excerpt

Osteoclasts are giant multinucleated cells that differentiate from hematopoietic cells in the bone marrow and carry out important physiological functions in the regulation of skeletal homeostasis as well as hematopoiesis. Osteoclast biology shares many features and components with cells of the immune system, including cytokine-receptor interactions (RANKL-RANK), intracellular signalling molecules (TRAF6) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26538571
DOI: 10.1093/jb/mvv112

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