Article

Cytochrome P450–catalyzed hydroxylation of Δ8-tetrahydrocannabinol and implications for pharmacogenetics

2026-06-18

Abstract excerpt

<title>Abstract</title> <p>The use of Δ8-tetrahydrocannabinol (Δ8-THC) has become increasingly prevalent in the United States but its metabolic pathways remain poorly characterized. This study aimed to identify the key enzymes responsible for the 11′-hydroxylation of Δ8-THC, its primary metabolic pathway, and assess the effect of metabolizing enzyme genotype on this activity. The intrinsic clearance of recombinan...

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Literature Corpus work: 45dad6a5-c1d1-5c50-94fd-c1bf8fd6f5bf
DOI: 10.21203/rs.3.rs-9808179/v1

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