Article
Genotype-Specific Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers.
Clinical and translational science - 1 Jan 2026
Etkins Jumar, So Gerald C, Lu Jessica Bo Li, Koyama Sachiko, Gisch Debora L, Melo Ferreira Ricardo, Cheng Ying-Hua, McClara Kelsey, Jun Joshua, Miller Matthew, Desta Zeruesenay, Eadon Michael T
Abstract excerpt
Cannabidiol (CBD) use has increased in America due to its widespread availability. Cannabidiol is metabolized by multiple polymorphic enzymes including CYP3A, CYP2C9, and CYP2C19. We sought to evaluate the genotype-specific adverse events and pharmacokinetic profiles of cannabidiol, 7-OH cannabidiol (an active metabolite), and 7-COOH cannabidiol. We completed a secondary analysis of an open-label, fixed-sequence,...
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