Article

Estrogen regulation and functional role of FGFR4 in estrogen receptor positive breast cancer

2024-03-20

Abstract excerpt

<h4>Background</h4> Resistance to endocrine therapy is a major challenge of managing estrogen receptor positive (ER+) breast cancer. We previously reported frequent overexpression of FGFR4 in endocrine resistant cell lines and breast cancers that recurred and metastasized following endocrine therapy, suggesting FGFR4 as a potential driver of endocrine resistance. In this study, we investigated the role of FGFR4 i...

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Literature Corpus work: 45b83ff5-000f-5d03-8d6f-d57e31ded345
DOI: 10.1101/2024.03.18.585626

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