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Article

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease

23 Jun 2020

Abstract excerpt

Mechanisms driving tumor progression from less aggressive subtypes to more aggressive states represent key targets for therapy. We identified a subset of luminal A primary breast tumors that give rise to HER2-enriched (HER2E) subtype metastases, but remain clinically HER2 negative (cHER2-). By testing the unique genetic and transcriptomic features of these cases, we developed the hypothesis that FGFR4 likely...

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PMID: 32573490
DOI: 10.1172/jci130323

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