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Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models.

Human molecular genetics - 28 May 2021

Kandasamy Lenin C, Tsukamoto Mina, Banov Vitaliy, Tsetsegee Sambuu, Nagasawa Yutaro, Kato Mitsuhiro, Matsumoto Naomichi, Takeda Junji, Itohara Shigeyoshi, Ogawa Sonoko, Young Larry J, Zhang Qi

Abstract excerpt

Posttranslational modification of a protein with glycosylphosphatidylinositol (GPI) is a conserved mechanism exists in all eukaryotes. Thus far, >150 human GPI-anchored proteins have been discovered and ~30 enzymes have been reported to be involved in the biosynthesis and maturation of mammalian GPI. Phosphatidylinositol glycan biosynthesis class A protein (PIGA) catalyzes the very first step of GPI anchor...

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Identifiers

PMID: 33607654
DOI: 10.1093/hmg/ddab052
PMCID: PMC8161520

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