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A CRISPR-based <i>Xenopus tropicalis</i> model for retroperitoneal liposarcoma with genetic control over the dedifferentiation process

2026-03-30

Abstract excerpt

Well- and dedifferentiated liposarcomas (WDLPS and DDLPS) are characterized by extensive copy- number alterations rather than recurrent gene-inactivating mutations, obscuring the molecular mechanisms that drive disease progression and, critically, the transition from well-differentiated to the more aggressive dedifferentiated tumor states. Despite marked differences in clinical behavior and prognosis, the regulato...

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Literature Corpus work
45abdd37-b05d-5129-a3eb-f070c0e8112a
DOI
10.64898/2026.03.26.714450
Open publication

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A CRISPR-based <i>Xenopus tropicalis</i> model for retroperitoneal liposarcoma with genetic control over the dedifferentiation processDOI 10.64898/2026.03.26.714450
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