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Article

PPARG governs adipogenic differentiation and cell state plasticity in well-differentiated and dedifferentiated liposarcoma

31 Jul 2026

Abstract excerpt

Well-differentiated and dedifferentiated liposarcoma (WD/DD LPS) represent a pathological continuum, often coexisting within the same tumor. While the dedifferentiated component is clinically aggressive, marked by rapid growth and metastatic potential, the evolutionary relationship between WD and DD LPS remains unknown. To investigate this, we performed single-nucleus RNA sequencing on matched WD and DD tumor...

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PMID: 40777457
DOI: 10.1126/sciadv.aea6516

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