Article

<i>De novo</i> design of modular and tunable allosteric biosensors

2020-07-20

Abstract excerpt

Naturally occurring allosteric protein switches have been repurposed for developing novel biosensors and reporters for cellular and clinical applications 1 , but the number of such switches is limited, and engineering them is often challenging as each is different. Here, we show that a very general class of allosteric protein-based biosensors can be created by inverting the flow of information through de novo de...

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Identifiers and source

Literature Corpus work: 45a8ef20-dd39-584b-affc-89ab114258f9
DOI: 10.1101/2020.07.18.206946

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