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Multimodal Integration of Protein Interactomes With Genomic and Molecular Data Discovers Distinct Rheumatoid Arthritis Endotypes.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Aug 2026

Rahimikollu Javad, Guha Roy Priyamvada, Kishore Akash, Lee Danica Morgan, Vanderlinden Lauren A, Nazarali Kiran, Zhang Fan, Ascherman Dana P, Schwartz Daniella M, Moreland Larry, Das Jishnu

Abstract excerpt

OBJECTIVE: Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease characterized by clinical and molecular heterogeneity, notably in the presence of anti-cyclic citrullinated peptide (CCP) antibodies. Patients with CCP+ RA exhibit more severe disease progression and distinct treatment responses compared to patients with CCP- RA. Although previous studies have investigated cellular and molecular...

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Identifiers

PMID: 41670344
DOI: 10.1002/art.70091
PMCID: PMC13430078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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