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Multi-modal integration of protein interactomes with genomic and molecular data discovers distinct RA endotypes

2025-08-05

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by clinical and molecular heterogeneity, notably in the presence of anti-cyclic citrullinated peptide antibodies (CCP). CCP positivity in RA patients is associated with more severe disease progression and distinct responses to treatment compared to CCP-patients. Although previous studies have investigated...

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Literature Corpus work
4ace0191-c72f-53b5-91bf-35aca01a2fd7
DOI
10.1101/2025.07.31.25331970
Open publication

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Multi-modal integration of protein interactomes with genomic and molecular data discovers distinct RA endotypesDOI 10.1101/2025.07.31.25331970
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