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Article

A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo.

Genes & development - 15 Jan 2011

Rajakumara Eerappa, Law Julie A, Simanshu Dhirendra K, Voigt Philipp, Johnson Lianna M, Reinberg Danny, Patel Dinshaw J, Jacobsen Steven E

Abstract excerpt

Cytosine DNA methylation is evolutionarily ancient, and in eukaryotes this epigenetic modification is associated with gene silencing. Proteins with SRA (SET- or RING-associated) methyl-binding domains are required for the establishment and/or maintenance of DNA methylation in both plants and mammals. The 5-methyl-cytosine (5mC)-binding specificity of several SRA domains have been characterized, and each one has a...

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PMID: 21245167
DOI: 10.1101/gad.1980311
PMCID: PMC3022260

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SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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