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Article

Number of HIV-1 founder variants is determined by the recency of the source partner infection.

Science (New York, N.Y.) - 3 Jul 2020

Villabona-Arenas Ch Julián, Hall Matthew, Lythgoe Katrina A, Gaffney Stephen G, Regoes Roland R, Hué Stéphane, Atkins Katherine E

Abstract excerpt

During sexual transmission, the high genetic diversity of HIV-1 within an individual is frequently reduced to one founder variant that initiates infection. Understanding the drivers of this bottleneck is crucial to developing effective infection control strategies. Little is known about the importance of the source partner during this bottleneck. To test the hypothesis that the source partner affects the number...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32631894
DOI: 10.1126/science.aba5443
PMCID: PMC7116289

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