Article
Srsf3 mediates alternative RNA splicing downstream of PDGFRα signaling in the facial mesenchyme.
Development (Cambridge, England) - 15 Jul 2021
Dennison Brenna J C, Larson Eric D, Fu Rui, Mo Julia, Fantauzzo Katherine A
Abstract excerpt
Signaling through the platelet-derived growth factor receptor alpha (PDGFRα) is crucial for mammalian craniofacial development, although the mechanisms by which the activity of downstream intracellular effectors is regulated to mediate gene expression changes have not been defined. We find that the RNA-binding protein Srsf3 is phosphorylated at Akt consensus sites downstream of PI3K-mediated PDGFRα signaling in...
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