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Article

PDGFRβ Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas

29 Apr 2016

Abstract excerpt

Carcinoma associated fibroblasts (CAFs) form the main constituents of tumor stroma and play an important role in tumor growth and invasion. The presence of CAFs is a strong predictor of poor prognosis of head and neck squamous cell carcinoma. Despite significant progress in determining the role of CAFs in tumor progression, the mechanisms contributing to their activation remain poorly characterized, in part due...

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PMID: 27128408
DOI: 10.1371/journal.pone.0154645

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