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Article

PCSK9 with a gain of function D374Y mutation aggravates atherosclerosis by inhibiting PPARα expression

26 Feb 2025

Abstract excerpt

The preprotein convertase, Bacillus subtilis protease/kexin type 9 serine protease (PCSK9), has garnered significant attention as a potential lipid lowering and therapeutic drug target for atherosclerosis (AS). Peroxisome proliferator-activated receptor alpha (PPARα) is expressed in various tissues and has crucial roles in lipid metabolism and the inflammatory response; however, the precise impact of PCSK9 on AS...

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PMID: 40011664
DOI: 10.1038/s41598-025-91061-5

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