Article

<i>ZNF180</i> modulates tumor intrinsic immunotherapy resistance in melanoma through driving plasticity

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Based on our previous study, we have identified ZNF180 , a zinc finger protein, as a pro-tumorigenic regulator in primary melanoma and a marker for poor prognosis. Herein, we report that ZNF180 -regulated pathway, hence ZNF180 -regulome, underlies resistance towards immune checkpoint inhibitions (ICIs). <h4>Methods</h4> To investigate regulatory roles of ZNF180 to conf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 003ccea1-ea0c-52f0-a232-618f545463cd
DOI: 10.1101/2025.09.16.676573

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>ZNF180</i> modulates tumor intrinsic immunotherapy resistance in melanoma through driving plasticityDOI 10.1101/2025.09.16.676573Read

Genomic landscape of the immunogenicity regulation in skin melanomas with diverse tumor mutation burden.Semantic proximity Read

Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor respondersSemantic proximity Read

Insights and Strategies of Melanoma Immunotherapy: Predictive Biomarkers of Response and Resistance and Strategies to Improve Response RatesSemantic proximity Read

OMIC signatures to understand cancer immunosurveillance and immunoediting: Melanoma and immune cells interplay in immunotherapySemantic proximity Read

Mi-2β promotes immune evasion in melanoma by activating EZH2 methylationSemantic proximity Read

Molecular Profiling of Core Immune-Escape Genes Highlights LCK Has Potential to Reshape TME in MelanomaSemantic proximity Read

Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic cutaneous melanomaSemantic proximity Read

A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanomaSemantic proximity Read

Hippo Signaling Pathway Regulates Cancer Cell–Intrinsic MHC-II ExpressionSemantic proximity Read

The landscape of immune checkpoint-related long non-coding RNAs core regulatory circuitry reveals implications for immunoregulation and immunotherapy responsesSemantic proximity Read

YIF1B Mutational Dysregulation Drives Cutaneous Melanoma Progression by Remodeling the TME.Semantic proximity Read

Identification of tumor-intrinsic drivers of immune exclusion in acral melanomaSemantic proximity Read