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Article

The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma

18 Mar 2023

Abstract excerpt

Resistance to immune checkpoint inhibitor therapies in melanoma is common and remains an intractable clinical challenge. In this study, we comprehensively profile immune checkpoint inhibitor resistance mechanisms in short-term tumor cell lines and matched tumor samples from melanoma patients progressing on immune checkpoint inhibitors. Combining genome, transcriptome, and high dimensional flow cytometric...

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PMID: 36934113
DOI: 10.1038/s41467-023-36979-y

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