Article

Decitabine reverses innate immune gene suppression in rare melanomas

2025-08-28

Abstract excerpt

Rare melanoma subtypes, including acral, mucosal, and uveal melanomas, exhibit limited responses to immune checkpoint inhibitors (ICIs), yet the molecular mechanisms of immune resistance remain poorly defined. Here, we performed transcriptomic profiling of patient-derived xenografts (PDXs) and publicly available tumor datasets to systematically compare intratumoral gene expression across cutaneous and rare melanom...

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Literature Corpus work: 096ad05a-6a12-542f-b370-0657db08bf85
DOI: 10.1101/2025.08.24.671992

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