Article

Metabolic adaptation to maternal hyperglycemia via ACLY-dependent acetyl-CoA production drives epigenetic remodeling and dysregulated placental development

2026-03-20

Abstract excerpt

<h4>Abstracts</h4> Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy that is paradoxically associated with both fetal overgrowth and fetal growth restriction (FGR). While maternal hyperglycemia is widely presumed to drive macrosomia through excessive nutrient supply, the mechanisms underlying FGR remain poorly understood. Here, using a mouse model that recapitulates the small-for...

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Literature Corpus work: 64f6f60f-88b5-5923-a52f-36a659cad3a8
DOI: 10.64898/2026.03.17.712507

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