Article
Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2012
Föller Michael, Hermann Andreas, Gu Shuchen, Alesutan Ioana, Qadri Syed M, Borst Oliver, Schmidt Eva-Maria, Schiele Franziska, vom Hagen Jennifer Müller, Saft Carsten, Schöls Ludger, Lerche Holger, Stournaras Christos, Storch Alexander, Lang Florian
Abstract excerpt
Chorea-acanthocytosis is an inevitably lethal genetic disease characterized by a progressive hyperkinetic movement disorder and cognitive and behavioral abnormalities as well as acanthocytosis. The disease is caused by loss-of-function mutations of the gene encoding vacuolar protein sorting-associated protein 13A (VPS13A) or chorein, a protein with unknown function expressed in various cell types. How chorein...
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