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Article

Kupffer cell programming by maternal obesity triggers fatty liver disease

18 Jun 2025

Abstract excerpt

Kupffer cells (KCs) are tissue-resident macrophages that colonize the liver early during embryogenesis1. Upon liver colonization, KCs rapidly acquire a tissue-specific transcriptional signature, mature alongside the developing liver and adapt to its functions1–3. Throughout development and adulthood, KCs perform distinct core functions that are essential for liver and organismal homeostasis, including supporting...

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PMID: 40533564
DOI: 10.1038/s41586-025-09190-w

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