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Article

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

Journal of leukocyte biology - 1 Aug 2014

Sauter Kristin A, Pridans Clare, Sehgal Anuj, Tsai Yi Ting, Bradford Barry M, Raza Sobia, Moffat Lindsey, Gow Deborah J, Beard Philippa M, Mabbott Neil A, Smith Lee B, Hume David A

Abstract excerpt

We investigated the role of CSF1R signaling in adult mice using prolonged treatment with anti-CSF1R antibody. Mutation of the CSF1 gene in the op/op mouse produces numerous developmental abnormalities. Mutation of the CSF1R has an even more penetrant phenotype, including perinatal lethality, because of the existence of a second ligand, IL-34. These effects on development provide limited insight into functions of...

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Identifiers

PMID: 24652541
DOI: 10.1189/jlb.2A0114-006R
PMCID: PMC4378363

Genes

CSF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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