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Evolution of the Cholesterol Biosynthesis Pathway in Animals

18 Jul 2019

Abstract excerpt

Cholesterol plays essential roles in animal development and disease progression. Here, we characterize the evolutionary pattern of the canonical cholesterol biosynthesis pathway (CBP) in the animal kingdom using both genome-wide analyses and functional experiments. CBP genes in the basal metazoans were inherited from their last common eukaryotic ancestor and evolutionarily conserved for cholesterol biosynthesis....

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PMID: 31397867
DOI: 10.1093/molbev/msz167

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