Article

Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain

2023-12-23

Abstract excerpt

In C. elegans , inter-cellular transport of the small non-coding RNA causing systemic RNA interference (RNAi) is mediated by the transmembrane protein SID1, encoded by the sid1 gene in the systemic RNA interference-defective ( sid ) loci. SID1 shares structural and sequence similarity with cholesterol uptake protein 1 (CHUP1) and is classified as a member of the cholesterol uptake family (ChUP). Although system...

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Literature Corpus work: 169e42b9-d716-56a4-a8a5-ec592869c241
DOI: 10.1101/2023.12.21.572875

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