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Enhanced proconvulsant sensitivity, not spontaneous rapid swimming activity, is a robust correlate of <i>scn1lab</i> loss-of-function in stable mutant and F0 crispant hypopigmented zebrafish expressing GCaMP6s

2025-01-16

Abstract excerpt

Zebrafish models of genetic epilepsy benefit from the ability to assess disease-relevant knock-out alleles with numerous tools, including genetically encoded calcium indicators (GECIs) and hypopigmentation alleles to improve visualization. However, there may be unintended effects of these manipulations on the phenotypes under investigation. There is also debate regarding the use of stable loss-of-function (LoF) al...

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Literature Corpus work
44be18dd-35e1-5341-a93a-19da44645085
DOI
10.1101/2025.01.15.633275
Open publication

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Enhanced proconvulsant sensitivity, not spontaneous rapid swimming activity, is a robust correlate of <i>scn1lab</i> loss-of-function in stable mutant and F0 crispant hypopigmented zebrafish expressing GCaMP6sDOI 10.1101/2025.01.15.633275
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