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Article

Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.

Cell reports - 26 Dec 2023

Zheng Yue, Zhao Chen, Song Qiulin, Xu Lichao, Zhang Bo, Hu Guangda, Kong Xiangfei, Li Shaowen, Li Xiang, Shen Yin, Zhuang Lenan, Wu Min, Liu Ying, Zhou Yan

Abstract excerpt

Appropriate histone modifications emerge as essential cell fate regulators of neuronal identities across neocortical areas and layers. Here we showed that NSD1, the methyltransferase for di-methylated lysine 36 of histone H3 (H3K36me2), controls both area and layer identities of the neocortex. Nsd1-ablated neocortex showed an area shift of all four primary functional regions and aberrant wiring of...

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Identifiers

PMID: 37995181
DOI: 10.1016/j.celrep.2023.113496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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