Article

Clinical and Cross-Domain Validation of an LLM-Guided, Literature-Based Gene Prioritization Framework

2026-01-23

Abstract excerpt

<h4>Background</h4> We previously published a literature-based pipeline for sepsis gene prioritization (PS3 and candidate genes) using an LLM-enabled retrieval and judging framework. Here, we extend that work to ask whether these prioritized genes show independent clinical validity and whether the same strategy generalizes to a drug–obesity– infection setting. <h4>Methods</h4> Using the original LLM-guided workf...

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Literature Corpus work: 9d62cf3b-52f6-5f31-bc13-8941c11ad6fa
DOI: 10.64898/2026.01.22.701191

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