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Systematic Meta-Analysis of Published Transcriptomic Prognostic Signatures and Development of a Robust Multi-Cohort Prognostic Classifier for Triple-Negative Breast Cancer

2026-07-10

Abstract excerpt

Triple-negative breast cancer (TNBC) exhibits pronounced molecular heterogeneity, yet the majority of published transcriptomic prognostic signatures suffer from limited reproducibility and have not achieved clinical translation. We systematically benchmarked 62 published TNBC prognostic signatures across 6 independent cohorts (n=1,357) using a unified analytical framework spanning multiple scoring algorithms, surv...

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Literature Corpus work
36ed9bc4-6275-51ae-9459-d5123460c9c8
DOI
10.64898/2026.07.09.737472
Open publication

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