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Article

Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.

Nature - 17 Jun 2010

Zheng Jimin, Jia Zongchao

Abstract excerpt

The Escherichia coli isocitrate dehydrogenase kinase/phosphatase (AceK) is a unique bifunctional enzyme that phosphorylates or dephosphorylates isocitrate dehydrogenase (ICDH) in response to environmental changes, resulting in the inactivation or, respectively, activation of ICDH. ICDH inactivation short-circuits the Krebs cycle by enabling the glyoxlate bypass. It was the discovery of AceK and ICDH that...

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PMID: 20505668
DOI: 10.1038/nature09088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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